VP/SVP, Biology and Translational Science

Responsibilities

• Drive discovery and early development strategy from target identification through IND and clinical development
• Define translational strategies to bridge preclinical findings to human studies, including biomarker implementation
• Lead the progression of protein biologics programs from hit identification through lead optimization and IND-enabling studies
• Oversee target identification, evaluation, and nomination grounded in human biology and immunology
• Build, mentor, and lead high-performing teams across biology, pharmacology, and translational science
• Manage productive collaborations with CROs, academic labs, and external partners
• Serve as a key scientific voice for board members, investors, and executive leadership

Requirements

• PhD or MD/PhD in pharmacology or biological disciplines (e.g., immunology, cellular biology, oncology, or biochemistry)
• 10+ years of direct pharmaceutical experience beyond postdoctoral work
• Deep expertise in immunology and a strong understanding of disease biology
• Proven track record advancing protein biologics from hit identification to IND
• Significant experience in target selection and nomination
• Demonstrated success in translational science and biomarker strategy
• Experience managing CROs and facilitating academic collaborations

Preferred Qualifications

• Prior experience working in smaller, high-growth startup environments
• Experience writing relevant pharmacology sections of IND documentation

About the Company

Prologue Medicines uses advances in structural predictions and large language models to functionally annotate the entire viral proteome to leverage millennia of viral evolution for the development of transformative medicines. As a Flagship Pioneering company, we are building a broad pipeline of therapeutics across several therapeutic areas to address humanity's most urgent health challenges.