Toxicology Research Scientist

Responsibilities

• Independently design, execute, and evaluate novel in vitro models to support early screening and investigative safety assessments.
• Deploy fit-for-purpose investigative assays and methodologies to address emerging safety questions and inform drug development decisions.
• Leverage laboratory automation and data analytics tools to accelerate the execution and interpretation of high-throughput experiments.
• Partner with cross-functional teams in Research and Preclinical Sciences to investigate mechanisms of toxicity and assess human relevance.
• Translate complex laboratory findings into clear, actionable insights and present recommendations to project teams and leadership.
• Evaluate emerging cellular models, screening platforms, and data analytics innovations to expand internal toxicology capabilities.
• Mentor junior scientists and build external collaborations across academic and industrial settings.

Requirements

• PhD with 2+ years of experience, Master's with 5+ years of experience, or Bachelor's with 8+ years of pharmaceutical industry experience.
• Demonstrated expertise in the design and execution of biochemical and cell-based screening assays.
• Strong hands-on experience in cell culture and assay development (e.g., immortalized cell lines, iPSC-derived models, or primary cells).
• Proficiency in R, Python, MATLAB, or similar scripting languages for data analysis.
• Broad foundation in molecular biology techniques, particularly in multi-well plate-based formats.
• Strong quantitative and analytical skills with the ability to derive insights from complex datasets.

Preferred Qualifications

• Experience in immunoassay development, including multiplexed ELISA platforms.
• Experience with cellular immunophenotyping via flow cytometry.

Benefits

• Medical, dental, and vision benefits.
• Generous paid time off, including a week-long company shutdown in the Summer and Winter.
• Educational assistance programs, including student loan repayment.
• 401(k) with company matching.
• Commuting subsidies and annual bonus/equity award eligibility.

About the Company

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company is recognized for its work in treating the underlying causes of multiple chronic, life-shortening genetic diseases and continues to advance a robust clinical pipeline across various modalities.