Staff/Senior Scientist, Bioconjugation Chemistry

About the Company

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease.

Responsibilities

• Partner with sample prep and assay development to screen and select conjugation chemistries for peptides and oligonucleotides
• Design bioconjugation workflows using NHS-ester chemistry, maleimides, isothiocyanate chemistry, and click chemistry
• Prepare bioconjugation reagents to enable studies from proof-of-concept through prototype-kitting
• Develop labeling strategies based on Edman Chemistry and selective C-terminal/N-terminal conjugation
• Develop site-specific labeling strategies for amino acid sidechains on native peptides
• Synthesize and purify peptide and oligonucleotide conjugates for assay testing
• Characterize conjugation efficiency, purity, and stability using HPLC, LC-MS/MS, NMR, CE, UV/Vis, and FTIR
• Scale conjugate synthesis from R&D quantities to prototype-grade supply
• Collaborate cross-functionally to troubleshoot conjugation failures and optimize workflows
• Maintain rigorous experimental documentation and author SOPs

Requirements

• MS or PhD in organic chemistry, chemical biology, biochemistry, or a related field
• Industry experience in bioconjugation chemistry
• 8+ years experience for Staff Scientist (with PhD) or 6+ years (with MS)
• 6+ years experience for Senior Scientist (with PhD) or 4+ years (with MS)
• Deep expertise in protein/peptide bioconjugation (NHS esters, maleimides, click chemistries)
• Experience with site-specific amino acid sidechain chemistry
• Track record developing novel blocking groups and conducting SAR studies
• Proficiency in HPLC, LC-MS/MS, UV/Vis, and CE
• Method-development mindset and ability to work independently

Preferred Qualifications

• Experience with solid-phase peptide synthesis (SPPS)
• Experience with peptide C-terminal chemistry (thioester formation, native chemical ligation)
• Familiarity with oligonucleotide chemistry and oligo-conjugation techniques
• Experience with scalable surface chemistry methods
• Familiarity with statistical and DOE-based experimental design
• Prior experience in an early-stage biotech or tools/diagnostics company

Benefits

• Employee Stock Option Plan
• 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
• Employer Retirement Contributions to 401(k)
• Generous Paid Time Off
• Paid Maternity and Paternity Leave
• Health & Wellbeing Program
• Office Snacks and Beverages
• Regular Team Bonding Activities