Staff/Senior Scientist, Assay Development (Chemistry)

About the Company

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease.

Responsibilities

• Optimize bioconjugation methods for peptide loading into the expansion assay
• Identify, characterize, and optimize peptide labeling during the ProSE sequencing assay
• Develop reagents and methods to maximize the stability of peptides, DNA, and peptide-DNA chimeras
• Partner with the Chemistry team to develop amino acid side-chain protection chemistries
• Design and determine the order of operations for chemical manipulations within the assay workflow
• Optimize selective cleavage chemistry workflows for use within the sequencing assay
• Employ analytical methods such as HPLC, LC-MS/MS, UV-Vis, and CE to characterize conjugation efficiency and purity

Requirements

• Advanced degree in organic chemistry, chemical biology, biochemistry, or a related field
• Industry experience designing multi-step chemical workflows in complex biological systems
• MS/PhD with 6+ years of experience (Senior Scientist) or 8+ years (Staff Scientist)
• Demonstrated experience in site-selective bioconjugation chemistry (click chemistry, NHS-ester coupling)
• Experience developing multi-step workflows using peptides and oligonucleotides
• Proficiency with analytical characterization (HPLC, LC-MS/MS, UV-Vis)
• Method-development mindset and ability to work in a cross-functional team

Preferred Qualifications

• Familiarity with nanopore or single-molecule sequencing chemistry
• Experience with solid-phase peptide synthesis (SPPS)
• Familiarity with statistical and DOE-based experimental design
• Prior experience in an early-stage biotech or tools/diagnostics company

Benefits

• Employee Stock Option Plan
• 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
• Employer Retirement Contributions to 401(k)
• Generous Paid Time Off
• Paid Maternity and Paternity Leave
• Health & Wellbeing Program
• Office Snacks and Beverages
• Regular Team Bonding Activities