Sr. Scientist

Responsibilities

• Lead, design and optimize research exploring next generation cell therapies using in-vivo CAR-T
• Isolate immune cells from leukopak or blood and execute evaluation of in-vivo CAR virus using in-vitro assays and in-vivo mice models
• Perform solid tumor research using cell culture, transfection, FACS, and cell-based functional assays
• Package and titer engineered viruses and characterize particles with protein and PCR based assays
• Generate, manage, and maintain critical data using ELN
• Maintain compliance with GLP and EHS protocols

Requirements

• PhD in Immunology or related discipline
• 4 years of experience in cell and gene therapy
• Extensive experience in immune cell-based analytics and assay development (flow-cytometry, cytotoxicity, ELISA/MSD)
• Experience with lentivirus particle characterization and quantification
• Proficiency in advanced gene delivery methods (LVV, VLP, or LNP)
• Strong experience with lentivirus production, titering, and transduction
• Track record of productivity evidenced by publications or patents

Preferred Qualifications

• In vivo CAR-T experience
• Experience with solid tumor models and in vivo cell-specific gene delivery
• Deep understanding of solid tumor models

About the Company

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases through advanced cell therapies including CAR-T, TCR-T, and NK cell-based immunotherapy.