Sr. Research Associate, NGS platform

Responsibilities

• Own end-to-end NGS workflows, including nucleic acid extraction, library preparation, and sequencing.
• Prepare RNA and DNA sequencing libraries using both kit-based and custom workflows.
• Perform library QC, pooling, and sequencing setup for Illumina and Nanopore platforms.
• Operate and maintain sequencing instruments to ensure consistent performance and uptime.
• Utilize automated liquid handling systems for sample extraction and processing.
• Troubleshoot workflow issues, identify root causes, and implement process improvements.
• Analyze and interpret QC metrics and experimental data to communicate results to stakeholders.
• Maintain accurate documentation within LIMS and ELN systems.

Requirements

• BS/BA in Biology, Molecular Biology, Genomics, or a related field.
• 2+ years of relevant experience in an NGS-focused laboratory setting.
• Hands-on expertise in sequencing library preparation and molecular biology techniques.
• Experience operating NGS instrumentation (e.g., Illumina, Nanopore, Qubit, Nanodrop).
• Proficiency with liquid handling automation (e.g., Echo, Mantis, or Hamilton).
• Strong troubleshooting skills and the ability to work independently in a fast-paced environment.
• Must be able to work onsite full-time in Cambridge, MA.

Preferred Qualifications

• 3+ years of experience in an NGS-focused lab.
• Experience with complex workflows such as single-cell genomics or low-input samples.
• Experience with high-throughput production workflows and automation.
• Background in supporting drug development or platform-based research programs.
• Ability to interpret complex sequencing QC metrics and data quality outputs.

Benefits

• Best-in-class healthcare coverage and voluntary benefit programs.
• Holistic well-being support, including fitness, mindfulness, and mental health resources.
• Family planning benefits, including fertility, adoption, and surrogacy support.
• Generous paid time off, including vacation, sabbatical, and global recharge days.
• Savings and investment opportunities.

About the Company

Moderna is pioneering the development of a new class of drugs made of messenger RNA (mRNA). We are building a leading mRNA technology platform to reimagine how medicines are created and delivered, aiming to bring transformative treatments to patients worldwide.