Sr. Principal Scientist/Director, DMPK & Bioanalytical Sciences

Responsibilities

• Lead DMPK and bioanalytical strategy across nonclinical and clinical programs, including PK, biomarker, and translational PD readouts
• Lead method development, qualification, and validation for bioanalytical assays (GLP/GCP-compliant as required)
• Design, execute, and oversee PK and PK-PD studies to evaluate delivery technologies and biomarker effects
• Manage and qualify CRO and external lab partners across bioanalytical and PK programs
• Support nonclinical toxicology programs in collaboration with internal teams and CROs
• Author nonclinical sections of regulatory filings (e.g., IND) and briefing documents
• Serve on the Research Leadership Team and represent DMPK/bioanalytical sciences in cross-functional discussions
• Manage and develop direct reports

Requirements

• PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, analytical chemistry, or a related field
• 8+ years of industry experience in DMPK, bioanalytical sciences, or a closely related function
• Experience with bioanalytical method development, qualification, and validation (e.g., mass spectroscopy, ELISA, NGS)
• Experience with ligand binding assays and multiplex immunoassay platforms (e.g., MSD, Luminex)
• Demonstrated experience in CRO oversight, including vendor qualification and study monitoring
• Experience designing and overseeing PK and PK-PD studies for novel delivery modalities
• Strong scientific writing skills for regulatory documents and internal study reports
• Experience supervising and developing scientific staff

Preferred Qualifications

• Experience in rare disease, genetic medicine, or nucleic acid / RNA therapeutics
• Familiarity with LNP platform biology and the delivery landscape
• Familiarity with GLP toxicology study design and ICH nonclinical guidelines
• Experience operating in a cross-functional leadership role at a clinical-stage biotech
• Experience with LC-MS/MS or related mass spectrometry platforms

Benefits

• Healthcare coverage
• Annual incentive program
• Retirement benefits
• A broad range of other competitive benefits

About the Company

Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. Founded by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics to treat diseases caused by premature termination codons.