Senior/Principal Scientist, ADC Conjugation Process Development

Responsibilities

• Implement and execute ADC Conjugation Process Development strategies using DOE and OFAT approaches
• Oversee ADC batch size progression from milligram to >100 g scales for PD, analytical, and formulation development
• Lead multi-gram scale purification optimization via UF/DF and preparative chromatography
• Serve as ADC Drug Substance subject matter expert for internal CMC teams and external CDMO partners
• Prepare essential documentation including SOPs, protocols, and reports for tech transfers and regulatory submissions
• Support authoring and reviewing of regulatory submission modules (IND, IMPD, BLA)

Requirements

• Bachelor's, Master's, or Ph.D. in Chemistry, Chemical/Biochemical Engineering, Biotechnology, or related field
• Minimum 5 years of biotech/biopharma experience with a Ph.D., 8 years with a Master's, or 10 years with a Bachelor's
• Required expertise in ADC or Conjugation/Bioconjugation Process Development
• Proven success in development and scale-up of ADC conjugation technologies and small molecule linker-payloads
• Experience with tech transfer and external CDMO engagement
• Strong understanding of conjugation, purification, and characterization approaches for ADCs
• Expertise in tangential flow filtration (TFF) at multi-gram scale
• Proficiency with analytical techniques including SEC, HIC, RP U/HPLC, LC-MS, icIEF, and CE-SDS
• Knowledge of GMP standards and regulatory guidelines for IND and BLA submissions

About the Company

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies, including antibody-drug conjugates.