Senior Technician

Responsibilities

• Carry out histological preparations of human and mouse tissues using existing or optimized immunohistochemical methods
• Analyze stained tissues using advanced imaging techniques, including confocal microscopy
• Perform molecular biology and biochemical experiments, such as western blotting, electrophoresis, RNA/DNA/Protein isolations, and PCR
• Manage the laboratory’s mouse colony through husbandry, genotyping, and various molecular, cellular, and behavioral assays
• Develop and maintain IACUC protocols
• Maintain laboratory equipment, records, and perform quality control/assurance activities
• Ensure laboratory compliance with state, local, and university regulations and manage reagent ordering

Requirements

• Bachelor's degree in a related field
• At least 1.5 years of related experience or equivalent in education and training

Preferred Qualifications

• Working knowledge of experimental methods in cellular and molecular neurobiology
• Prior experience working with mouse models of disease
• Comfort working with human-derived tissues and samples
• Experience in RNA sequencing and computational methods
• Proficiency in Excel and ability to use internet resources for literature searches and database mining
• Strong organizational skills and high attention to detail

About the Company

Columbia University is a world-class research institution. This position is located within Dr. Neil Shneider’s lab in the Motor Neuron Center at Columbia University Irving Medical Center, focusing on the molecular and cellular mechanisms of neurodegeneration in ALS, frontotemporal dementia (FTD), and related disorders.