Senior Scientist, RNA Delivery

About the Company

Conception is pioneering the future of reproductive biology by generating functional human eggs from induced pluripotent stem cells (iPSCs). Our mission is to unlock new possibilities for fertility, reproductive health, and genetic diversity.

Responsibilities

• Develop RNA delivery workflows for payload expression in different cell types and culture set ups
• Apply RNA delivery strategies to improve and accelerate Conception’s differentiation platform
• Optimize RNA format, delivery chemistry and formulation, dose, timing, repeat delivery, expression, viability, and biological activity
• Build assays to measure delivery efficiency, target expression, and differentiation outcomes
• Support screening workflows for RNA constructs, genes of interest, delivery conditions, and combinatorial perturbations
• Collaborate across differentiation, cell engineering, and computational teams

Requirements

• PhD or equivalent experience in RNA Biology, Cell Biology, Stem Cell Biology, Bioengineering, Synthetic Biology, Developmental Biology, or a related field
• Hands-on experience delivering RNA into mammalian cells in various formats
• Experience with up to date RNA delivery technologies (LNPs, ligand conjugates, exosomes, electroporation, etc.)
• Experience with standard readouts such as flow cytometry, imaging, qPCR, reporter assays, or RNA-seq
• Experience delivering RNA or nanoparticles into complex culture systems
• Experience optimizing delivery parameters such as dose, formulation, timing, repeat dosing, expression duration, toxicity, and biological effect
• Strong experimental design, troubleshooting, documentation, and data interpretation skills

Preferred Qualifications

• Experience with iPSCs, ESCs, primary cells, differentiating cells, or other difficult-to-transfect cell types
• Experience using RNA-based differentiation approaches
• Experience with different RNA format design, production, purification, characterization, or delivery
• Experience with medium- or high-throughput screens, ORF libraries, combinatorial perturbations, or barcoded workflows
• Familiarity with scRNA-seq or related single-cell approaches
• Familiarity with developmental biology, reproductive biology, germ cell development, ovarian biology, or organoid systems