Senior Scientist, Proteomics

Responsibilities

• Operate, maintain, and troubleshoot state-of-the-art LC-MS instrumentation, including Orbitrap Tribrid platforms with FAIMS
• Develop, optimize, and execute targeted chemoproteomics workflows to support drug discovery programs
• Design and improve scalable sample preparation and experimental workflows for high-throughput proteomics applications
• Analyze and interpret large-scale proteomics datasets using quantitative and statistical approaches
• Collaborate closely with proteomics, biology, chemistry, and computational teams to design experiments and guide project strategy
• Develop and implement innovative chemical proteomics technologies to enhance platform capabilities
• Communicate findings and technical advances clearly across cross-functional teams

Requirements

• Ph.D. in analytical chemistry, chemical biology, biochemistry, or a related discipline with 4+ years of industry experience, or M.S. degree with 6+ years of industry experience
• Extensive hands-on experience with mass spectrometry-based proteomics workflows and instrumentation
• Experience with quantitative proteomics methods including TMT, DIA, PRM, or related approaches
• Experience with targeted chemoproteomics workflows and applications
• Proficiency in analyzing complex, large-scale proteomics datasets using Python or R
• Expert level understanding of proteomics data analysis software (e.g., MSFragger, ProteomeDiscoverer, Spectronaut, MaxQuant)
• Strong understanding of experimental design, assay optimization, and quantitative data interpretation

Preferred Qualifications

• Experience with peptide mapping and/or intact mass spectrometry
• Experience with laboratory automation platforms (e.g., Hamilton, Agilent Bravo)

Benefits

• Healthcare coverage
• Annual incentive program
• Retirement benefits
• Broad range of other company benefits

About the Company

Expedition Medicines is a privately held, early-stage biotechnology company pioneering the emerging field of Protein Editing. We create small molecules that edit protein structure and function to unlock presently undruggable targets. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning to enable generative design. Expedition Medicines is backed by Flagship Pioneering.