Senior Scientist, Pharmacology

About the Company

Arbor Biotechnologies is a next-generation gene editing company based in Cambridge, MA, advancing a pipeline of novel gene editing therapeutics to address a wide range of genetic conditions. The company’s unique suite of optimized gene editors aims to unlock access to new gene targets for diseases of high unmet need, specifically focusing on genomic diseases of the liver and CNS.

Responsibilities

• Serve as pharmacology lead in cross-functional nonclinical teams
• Design and execute in vivo pharmacology studies for neuroscience gene-editing programs
• Analyze and interpret in vivo gene editing data, including molecular biology and histology readouts
• Manage 1-2 research associates, providing scientific guidance and prioritizing work
• Prepare study reports and summaries for regulatory filings
• Oversee CRO studies to ensure high-quality, timely deliverables

Requirements

• PhD or equivalent degree in Pharmacology, Neuroscience, Genetic Medicine, or Biomedical Sciences
• 2-5 years of industry experience in in vivo pharmacology studies for neuroscience indications
• Experience with AAV-based therapeutic programs
• Expertise in molecular readouts (DNA, RNA, and/or protein-based assays)
• Experience overseeing outsourced studies and collaborating with CRO partners
• Experience managing or mentoring junior scientists or research associates
• Experience preparing study reports for regulatory filings

Preferred Qualifications

• Experience with gene editing and/or ALS therapeutic programs
• Experience with non-human primate biodistribution studies and/or IND-enabling studies
• Histology experience, including ISH and/or IHC