Senior Scientist, Model Systems

About the Company

Relation is a sector-defining TechBio company developing transformational medicines. We leverage single-cell multi-omics, functional assays, and machine learning to understand human biology and discover therapies for devastating diseases.

Responsibilities

• Integrate human primary cell lines into robust monoculture and co-culture models for large batch production and high throughput readouts.
• Characterise and optimise multiplexed imaging and biochemical assays for functional phenotyping.
• Transition manually developed perturbation models into automated arrayed screens.
• Contribute to the development of new technologies, workflows, and operational infrastructure.
• Perform data analysis and implement quality assurance protocols.
• Communicate outcomes to cross-functional teams across biology, machine learning, and automation disciplines.

Requirements

• PhD with 5+ years of experience in assay development and/or target validation.
• Strong background in culturing primary and immortalised cell lines.
• Hands-on experience in high-content imaging and data interpretation using cell painting.
• Scientific knowledge of fibrosis across various tissues.
• Knowledge of CRISPR/Cas9 gene editing in 2D and 3D cell systems.
• Prior experience running pathway-modifying perturbation screens.
• Experience with automated laboratory systems.
• Extensive knowledge in industry-standard large ‘omic dataset handling.
• Ability to thrive in a fast-paced, collaborative, and matrixed biotech environment.