Senior Scientist, LNP Process and Development

Responsibilities

• Support process development and optimization for LNP formulation and scale-up, focusing on mixing parameters, encapsulation efficiency, and reproducibility
• Design and execute experiments to improve the performance and manufacturability of LNPs encapsulating modified DNA and mRNA
• Collaborate with internal and external teams to support the characterization and evaluation of LNP formulations
• Assist with technology transfer and scale-up activities, including coordination with manufacturing teams or external partners
• Analyze and interpret experimental data, maintain accurate documentation, and communicate findings to project teams
• Stay current with advancements in LNP technologies and nucleic acid delivery approaches

Requirements

• PhD in Chemical Engineering, Pharmaceutical Sciences, Bioengineering, or a related field with 3+ years of industry experience
• M.S. with 8+ years of relevant industry experience, or a Bachelor's degree with 10+ years of experience
• Strong background in process development, scale-up, or manufacturing of nanoparticle or LNP-based systems
• Experience working with nucleic acid formulations (e.g., mRNA, DNA)
• Familiarity with T mixing (or similar) and characterization techniques such as DLS and encapsulation assays
• Demonstrated ability to design experiments, analyze data, and solve complex technical problems

Benefits

• Competitive compensation and benefits package
• Opportunity to work at the forefront of LNP formulation innovation
• Collaborative, science-driven culture with high-impact research

About the Company

Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy to address currently untreatable diseases. Founded by Flagship Pioneering, Serif is part of an ecosystem of innovation dedicated to solving major needs in human health and sustainability.