Senior Scientist II, Immunobiology

Responsibilities

• Drive scientific value from external collaborations by building peer-to-peer relationships with academic scientists.
• Act as a scientific bridge between the Oxford Immunobiology group and internal stakeholders in precision medicine and genomics.
• Propose orthogonal approaches to validate clinical dataset observations using primary tissue assays.
• Co-lead the Enabling Biology cross-site working group to establish key assays, models, and biological capabilities.
• Lead biological pathway deconvolution and develop target validation packages for the AbbVie portfolio.
• Supervise and mentor lab-based scientists across the Immunobiology and Novel Therapeutics groups.
• Maintain a presence at the bench to support research activities and tool validation.

Requirements

• BSc, MSc, or PhD in a relevant scientific field, including industry experience or equivalent.
• Proven experience in matrixed project leadership.
• Extensive knowledge of immunological techniques, including primary cell culture and functional in vitro/ex vivo assays (e.g., myeloid, lymphocytic, or mesenchymal cells).
• Proficiency in flow cytometry and fluorescence microscopy.
• At least two years of practical experience with complex in vitro or in vivo model systems.
• Demonstrated research experience within an immunological disease area.
• Experience in biological pathway deconvolution or formal target validation.

Preferred Qualifications

• Experience with advanced techniques such as spectral flow cytometry and high-content imaging.
• Proficiency in 'omics technologies, including bulk/single-cell RNAseq, proteomics, or spatial transcriptomics.
• Experience establishing explant or biopsied-tissue based bioassays.
• Background in working with organoids, organ-on-a-chip models, or high-throughput assays.
• Familiarity with antibody binding techniques such as ELISA, FACS, or SPR.

About the Company

AbbVie is a global biopharmaceutical company dedicated to discovering and delivering innovative medicines that solve serious health issues. Our Oxford R&D hub integrates drug design, human-centric biology, and mechanistic clinical testing to advance novel therapies for immunological diseases.