Posted a month ago
Senior Scientist - Experimental Protein Design for Target Discovery
AmgenSenior Scientist - Experimental Protein Design for Target Discovery
Perks & benefits
Health InsuranceMedical InsurancePaid Leave
Requirements
PhD, PharmD, or MD with post-doc, Master's with 3 years experience, Bachelor's with 5 years experience, Protein expression and purification, Biochemical characterization, Flow cytometry, SPR, High-throughput experimentation
Skills
Protein EngineeringFlow Cytometry
About the role
Responsibilities
- Translate computational protein designs into experimentally testable minibinders and antibodies across multiple targets
- Lead high-throughput workflows for binder expression, purification, and characterization
- Develop cellular assays for binder–target evaluation
- Partner with molecular biology teams to establish construct generation and binder library production workflows
- Develop strategies to format de novo binders into appropriate modalities, such as multispecifics
- Analyze and interpret experimental data to guide iterative design-build-test cycles
Requirements
- PhD, PharmD, or MD with relevant post-doc experience in protein design
- Master's degree with 3 years of protein engineering experience
- Bachelor's degree with 5 years of protein engineering experience
- Experience in protein expression and purification
- Proficiency in biochemical characterization and biophysical techniques
Preferred Qualifications
- Experience in binder hit validation using flow cytometry and SPR
- Experience with different expression hosts including cell-free, E. coli, and mammalian cells
- Knowledge of protein structure–function relationships and protein–protein interaction engineering
- Experience with automation platforms and high-throughput experimentation
- Experience supporting phenotypic screening, receptor biology, or early target characterization
- Strong organizational and communication skills for cross-functional collaboration
Benefits
- Comprehensive medical, dental, and vision coverage
- Retirement and Savings Plan with company contributions
- Discretionary annual bonus program
- Stock-based long-term incentives
- Award-winning time-off plans
About the Company
Amgen is a leading biotechnology company dedicated to discovering, developing, and delivering innovative human therapeutics. Since 1980, Amgen has focused on serving patients living with serious illnesses in therapeutic areas including Oncology, Inflammation, General Medicine, and Rare Disease.
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Amgen · South San Francisco
