Senior Scientist, Computational Genomics

Responsibilities

• Deliver computational research projects with high autonomy, including project design, implementation, interpretation, and reporting results to senior leadership
• Collaborate with cloud engineers to establish infrastructure for processing and storing large-scale genomics datasets
• Integrate multiple NGS data types into coherent analyses, managing the pipeline from raw input files to variant calls and higher-level insights
• Develop probabilistic and Bayesian models that rigorously incorporate priors, uncertainty, and missing data to inform scientific decision-making
• Interact with external advisors to leverage expert input and build high-quality scientific relationships

Requirements

• Ph.D. in biology, statistics, genetics, computational biology, or a related quantitative discipline
• 5+ years of relevant post-academic or industry experience with an excellent research track record
• Deep expertise in analyzing genomics data derived from Illumina sequencing platforms
• Proven experience processing next-generation sequencing (NGS) data end-to-end (alignment, QC, and variant calling)
• Experience integrating and jointly analyzing multi-modal sequencing datasets, specifically DNA and RNA
• Expertise in statistical genetics, including computing and adapting polygenic risk scores
• Proficiency in building probabilistic statistical models that account for uncertainty and incomplete observations
• Ability to operate effectively in a fast-moving, ambiguous startup environment with high ownership

About the Company

FL122 is a new venture founded by Flagship Pioneering, pioneering genomic technologies at the intersection of human health and assisted reproduction. As part of the Flagship ecosystem—which has created groundbreaking companies like Moderna—we are building a scientific platform to solve major needs in human health through novel biological and engineering approaches.