Senior Scientist, Biology

Responsibilities

• Design, execute, and analyze complex in vitro and ex vivo experiments to support discovery and preclinical research programs.
• Lead and perform multi-parameter flow cytometry assays, including panel design, optimization, and data interpretation.
• Perform and optimize cell isolation and cell sorting (e.g., FACS, MACS) from various tissues and biological samples.
• Execute in vivo mouse studies, including disease model development, dosing, tissue collection, and phenotypic characterization.
• Develop and apply siRNA-based approaches for target validation and mechanistic studies.
• Design and perform microscopy-based experiments, including fluorescence, confocal, and live-cell imaging.
• Analyze and present experimental findings to cross-functional teams and senior leadership.
• Mentor junior scientists and contribute to a collaborative, innovative research environment.

Requirements

• Ph.D. in Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, or a related field.
• 6+ years of relevant experience (or an M.S. with substantial industry experience).
• Strong expertise in flow cytometry and cell sorting (FACS), including panel design and troubleshooting.
• Extensive experience with in vivo mouse models and in vitro experimental techniques.
• Demonstrated expertise in siRNA design, delivery, and functional validation.
• Hands-on experience with microscopy platforms (fluorescence, confocal, or high-content imaging).
• Strong quantitative data analysis and statistical skills.

Preferred Qualifications

• Experience in translational research, drug discovery, or preclinical therapeutic development.
• Experience with single-cell or spatial biology technologies (e.g., scRNA-seq, spatial transcriptomics).
• Proficiency in molecular biology techniques such as qPCR, Western blotting, or ELISA.
• Experience managing CROs or external academic collaborators.
• Proficiency with image analysis software like ImageJ, CellProfiler, or Imaris.

About the Company

FL106 Inc. is a privately held, early-stage biotechnology company focused on developing novel drug delivery modalities. Backed by Flagship Pioneering, FL106 leverages strategic resources to advance innovative platforms from validation to clinical impact.