Senior Research Associate, Protein Sciences

About the Company

Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company.

Responsibilities

• Perform as a hands-on protein production associate to help fully enable Septerna’s Native Complex™
• Carry out medium and large-scale protein production utilizing a variety of techniques including FPLC, gravity flow, microscale, and magnetic bead purification
• Qualify proteins utilizing techniques including SDS-PAGE, flow cytometry, fluorescent SEC, and DSF
• Work collaboratively with Discovery Biology teams in ensuring proper prioritization and timelines of cell culture requests
• Laboratory notebooking, data analysis and documentation

Requirements

• BS with 4+ years of hands-on relevant experience in a biotechnology or pharmaceutical setting
• 2+ years demonstrated expertise in large-scale protein purification
• Experience with affinity chromatography, ion-exchange chromatography, size exclusion chromatography, and SDS-PAGE
• Ability to write and follow standard operating procedures
• Strong skills in managing multiple simultaneous projects
• Clear and effective verbal and written communication skills

Preferred Qualifications

• Prior experience with basic protein quality control techniques (SDS-PAGE, fSEC, DSF)