Senior Principal Scientist, Process Chemistry

Responsibilities

• Lead technical teams in designing, executing, and interpreting complex laboratory experiments for route development, process optimization, and scale-up.
• Develop fit-for-purpose processes for early- and late-stage programs, ensuring safety, robustness, and scalability.
• Lead the authorship of patents, scientific publications, and regulatory documents.
• Apply modern synthetic organic chemistry principles, high-throughput experimentation, and mechanistic insight to accelerate development.
• Communicate scientific strategy, risks, and solutions to project teams, leadership, and partner functions.
• Mentor junior staff and foster a collaborative, scientifically rigorous environment.
• Drive technology transfer and manage partner interactions to enable external development campaigns.

Requirements

• PhD in Organic Chemistry.
• 8+ years of industry experience in pharmaceutical process development.
• Proven expertise in route design, scale-up, and GMP manufacturing.
• Deep understanding of synthetic organic chemistry, reaction mechanisms, and modern purification technologies.
• Demonstrated scientific impact through peer-reviewed publications, patents, or conference presentations.
• Experience supporting development from preclinical through commercial stages.
• Experience in regulated environments, including GMP operations and authoring regulatory submissions.

Preferred Qualifications

• Proficiency in current Good Manufacturing Practices (GMP).
• Skill in reaction modeling and simulation using computational tools such as DynoChem, gPROMS, or Aspen.
• Experience developing drug-linkers for ADCs, PROTACS, or other targeted mixed-modality therapeutics.
• Experience with technology transfer and oversight of external development work.
• Experience working at innovator pharmaceutical companies.

Benefits

• Competitive annual base salary and performance-based bonus target.
• Eligibility for share-based long-term incentive programs.
• Comprehensive health benefits including medical, prescription drug, dental, and vision coverage.
• 401(k) plan with Pfizer matching contributions and additional retirement savings contributions.
• Paid vacation, holidays, personal days, and medical/parental leave.

About the Company

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Through our Research and Development efforts, we translate advanced science and technologies into impactful therapies and vaccines, working across all facets of development to improve outcomes for patients and healthcare providers worldwide.