Senior Principal Scientist, Pre-Formulation and Materials Science

Responsibilities

• Provide scientific leadership and strategic direction for understanding molecular structure, solution behavior, and permeation characteristics to enable optimal drug formulation.
• Integrate pharmaceutics, physical organic chemistry, materials science, and biopharmaceutics principles into drug candidate screening and design.
• Lead matrix teams of scientists to deliver portfolio breakthroughs and set direction for advances in oral small molecule drug delivery.
• Develop and advance concepts of early translational biopharmaceutics to improve predictive capabilities between in vitro and in vivo performance.
• Mentor and teach colleagues across the organization while cultivating effective relationships with internal partners in Medicinal Design and Clinical Pharmacology.
• Conduct novel scientific research and present significant findings through internal and external publications and presentations.

Requirements

• PhD in Pharmaceutics, Pharmaceutical Sciences, Materials Science, Physical Chemistry, or a related discipline with 8+ years of relevant experience.
• Alternatively, a BS/MS in a related field with 10-12 years of relevant industry experience in small molecule drug product design.
• Strong background in small molecule formulation, early biopharmaceutics, materials science, or pharmacokinetics.
• Knowledge of biology, pharmacology, and drug discovery through Proof of Concept (POC) studies.
• Experience using and interpreting biophysical modeling and physicochemical transport phenomena (solubility, dissolution, and permeation).
• Proven ability to work effectively within cross-disciplinary teams in a matrix environment.
• Excellent organizational and communication skills, with the ability to work both independently and collaboratively.

Preferred Qualifications

• Proven track record of supervising, mentoring, and coaching scientists.
• Deep understanding of drug discovery and development concepts.
• Experience actively developing scientific initiatives and managing external collaborations.
• Demonstrated ability to influence and collaborate with peers to achieve business impact.

About the Company

Pfizer is a global leader in healthcare, dedicated to unearthing innovative therapies that transform millions of lives. We foster a culture of individual ownership and scientific excellence to make the world a healthier place.