Senior Principal Scientist, Peptide Therapeutics

Responsibilities

• Drive the discovery of novel peptide therapeutics by governing the design and synthesis of innovative peptides and peptidomimetics.
• Lead scientific and project teams from concept to clinic, guiding research from early hit identification through lead optimization.
• Implement rational drug design strategies using peptide synthesis, conformational analysis, and computational methods to optimize pharmaceutical properties.
• Champion cross-functional collaboration by serving as a key scientific partner to Research Biology and Drug Discovery teams.
• Provide scientific leadership and mentorship to junior scientists and contribute to the prioritization of team objectives.
• Oversee the analysis and interpretation of complex analytical data, including mass spectrometry, HPLC, and NMR, to ensure compound identity and purity.

Requirements

• Ph.D. or postdoctoral degree in Organic Chemistry, Medicinal Chemistry, or a related field.
• Minimum of 7 years of experience in the biotechnology or pharmaceutical industry with a track record of advancing drug candidates into clinical testing.
• Mastery in complex molecule organic synthesis, including automated solid-phase peptide synthesis and solution-phase small molecule synthesis.
• Expertise in high-throughput and parallel synthesis for library generation.
• Proficiency in analyzing and interpreting analytical data such as HPLC, Mass Spectrometry, and NMR.
• Experience with computational modeling and simulation, including conformational sampling and molecular dynamics (MD) simulations.
• Proficiency in structure-based and ligand-based drug design using software such as Schrödinger, MOE, or Maestro.

Preferred Qualifications

• Deep knowledge of macrocyclic peptides and related library-based screening technologies (e.g., OBOC, mRNA display, AS/MS).
• Familiarity with machine learning and AI-driven platforms for predicting peptide properties and optimizing sequences.
• Demonstrated success in a leadership role guiding multidisciplinary teams within a globally matrixed organization.

Benefits

• Competitive salary range ($168,600 to $313,000 based on experience and location).
• Discretionary annual bonus based on individual and company performance.
• Comprehensive benefits package.
• Relocation benefits available.

About the Company

Genentech, a member of the Roche group, is a pioneer in the biotechnology industry. We are dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases.