Senior Director, Biotherapeutics

Responsibilities

• Manage and mentor internal protein scientists and protein engineers
• Build and focus teams in a capital-efficient manner to support pipeline needs
• Foster collaboration between biotherapeutics, AI/ML protein design, and pharmacology teams
• Support discovery and characterization of shuttled therapeutics as project lead
• Map out critical path activities through IND-enabling studies
• Engage with consultants, CROs, and CDMOs to accelerate program progression
• Set strategy for developability assessment and early-stage de-risking
• Prepare data packages for partnering discussions and investor presentations
• Establish development candidate nomination criteria

Requirements

• Extensive experience in biotherapeutics across various protein modalities
• Proven track record engineering antibodies for clinical development
• Deep knowledge of state-of-the-art protein engineering approaches
• Experience with protein expression systems, purification, and characterization
• Prior experience liaising with CDMOs

Preferred Qualifications

• Expertise with novel modalities like ADCs, tissue-targeted therapeutics, and bispecific antibodies
• Understanding of high-throughput screening and bioanalytical technologies
• Experience with generative AI models for protein or oligonucleotide design

Benefits

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• On-site gym, lunch, and commuter support

About the Company

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines.