Senior Associate Engineer, Upstream Development

Responsibilities

• Lead and collaborate in operational activities related to bioreactor set-up, monitoring, harvest, and maintenance
• Develop, test, and implement recipe scripting for fed-batch fermentation feeding controls
• Provide engineering support for the design, implementation, and qualification of scale-down models
• Author SOPs, process flow diagrams, and batch records
• Analyze and present fermentation data at internal project meetings
• Participate in upstream database management and documentation in electronic notebooks

Requirements

• BS in Chemical Engineering or a related discipline with 5+ years of relevant Pharma/Biotech industry experience, or MS with 2+ years of experience
• Hands-on experience with fermentation and/or primary recovery unit operations
• Strong understanding of bioreactor design, operation, and controls
• Proven knowledge of aseptic techniques
• Familiarity with DoE (Design of Experiments) principles and software

Preferred Qualifications

• Experience with pilot scale fermentation and recovery equipment
• Mechanical and technical knowledge of primary recovery unit operations such as homogenization, centrifugation, and depth filtration
• Understanding of fermentation scale-up and development of scale-down models
• Familiarity with regulatory requirements of biotherapeutics
• Experience with late-stage process characterization

About the Company

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. We are dedicated to eradicating or treating infections such as invasive pneumococcal disease, Group A Strep, and Shigella through creative and intellectual diversity.