Scientist/Senior Scientist

About the Company

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells.

Responsibilities

• Develop functional assays and pre-clinical models to measure endothelial cell function
• Collaborate with Functional Genomics and Predictive Modeling teams to test reprogramming hypotheses at scale
• Measure the impact of mRNA reprogramming medicines on endothelial cell function
• Engineer in vivo nucleic acid delivery methods for endothelial cells
• Analyze and interpret experimental data to drive pre-clinical decision making

Requirements

• Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
• Experience with primary cell isolation and functional characterization
• Experience working with mouse models (e.g. kidney, cardiovascular, or cognitive disease models)
• Experience with transgenic manipulation of primary cells either ex vivo or in vivo

Preferred Qualifications

• History of contributing to a drug development program at the pre-clinical or clinical development stage
• Experience leading the design and execution of pre-clinical studies in mouse models
• Experience with single cell genomics methods
• Experience with pooled screening approaches using bulk or single cell read-outs

Benefits

• Health, dental, and vision insurance
• 401(k) with company match
• Paid parental leave
• Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
• Meals and snacks on-site