Scientist, RNA Chemistry

Responsibilities

• Perform synthesis of modified RNA oligonucleotides (ASO, siRNAs) incorporating diverse sugar and backbone chemistries
• Troubleshoot and optimize synthesis methods for high quality oligonucleotides
• Interpret analytical data (HPLC, LCMS) to improve purity and yields
• Carry out purification (anion exchange, reverse phase) and characterization (LCMS, UV, melting temperature)
• Register synthesized oligonucleotides in databases and report experiments in ELN
• Contribute to oligonucleotide design and hit-to-lead optimization
• Generate intermediates for antibody-oligonucleotide conjugates
• Collaborate cross-functionally to define deliverables and timelines
• Perform lab maintenance and present data at internal meetings

Requirements

• PhD in Chemistry or related discipline with 2 years of experience, or MSc with 8+ years of industry experience
• Hands-on experience with oligonucleotide synthesis and purification platforms (MerMade, K&A, AKTA Oligopilot)
• Experience with biochemical and analytical assays for modified RNA oligonucleotides
• Ability to independently execute experimental work and interpret complex data
• Strong cross-functional collaboration skills

Preferred Qualifications

• Postdoctoral experience
• Experience with oligonucleotide conjugation, including antibody conjugation

About the Company

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases by developing therapeutics that target muscle and the central nervous system (CNS).