Scientist-Principal Scientist, Protein Design & Structure

About the Company

Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company’s platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure.

Responsibilities

• Design, execute, and optimize constructs for GPCR expression
• Drive the development of high-throughput protein expression (mammalian/insect cells) and purification workflows
• Ensure high-quality, homogeneous protein for assays and structural studies (Cryo-EM)
• Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects
• Serve as a subject matter expert on GPCR protein sciences in internal and external project teams
• Document experiments in ELN and present data at internal/external meetings

Requirements

• Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field with 2+ to 8+ years of experience depending on level
• Deep knowledge of GPCR biology and membrane protein structure-function relationships
• Proven expertise in molecular biology including cloning, construct design, and mutagenesis
• Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC)
• Familiarity with protein stabilization techniques
• Excellent communication, interpersonal, and leadership skills

Preferred Qualifications

• Experience with structural biology methods such as Cryo-EM data collection and processing
• Experience in laboratory automation in protein sciences & purification
• Background in computational protein design tools like Rosetta or AI/ML-driven prediction

Benefits

• Full coverage of annual deductibles and monthly premiums for medical, dental, and vision insurance
• 401(k) match program
• Massachusetts transportation subsidy
• Equity
• Unlimited paid time off
• Disability and life insurance