Scientist, Mechanistic Biology

Responsibilities

• Design and execute mechanistic studies on hit compounds
• Dissect signaling pathways to map compound mechanism of action
• Interrogate protein-protein interactions
• Prepare and analyze NGS libraries
• Develop and deploy functional cell-based assays to characterize novel pharmacology

Requirements

• BS, MS or PhD in Cell Biology, Biochemistry, or related field
• 5-7+ years of relevant industry experience if without a PhD
• Experience elucidating novel biology underlying small-molecule mechanism of action in drug discovery
• Experience with mammalian cell line work and associated assays
• Experience with stable cell line generation (lentiviral and CRISPR-based systems)
• Proficiency in co-IP/pull-down assays, RNA-seq, global proteomics, and flow cytometry
• Experience with plasmid design/cloning
• Experience with small molecule drug development campaigns (hit discovery, validation, dose-response, SAR, and MOA)
• Experience with cell signaling, pathway analysis, and PTM analysis
• Experience with protein-protein interaction techniques (e.g., BRET, APEX/BioID, AlphaScreen)
• Experience with NGS library prep, sequencing, and analysis

Preferred Qualifications

• Experience with PROTAC or next-gen IPM technologies
• Experience working at the interface of mechanistic biology and chemistry
• Experience advancing research to the clinic
• Experience managing CROs

Benefits

• Strong equity incentives
• Top tier medical, dental, and vision coverage plus One Medical membership
• 401(k) retirement plans
• Education and health/fitness incentive programs
• Meditation retreats
• Reading budget

About the Company

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs) using their OmniTAC drug discovery engine to overcome therapeutic challenges.