Scientist, LNP Process and Development

Responsibilities

• Support process development and optimization activities for LNP formulation and scale-up, including mixing parameters, encapsulation efficiency, and reproducibility
• Design and execute experiments to improve the performance and manufacturability of LNPs encapsulating modified DNA and mRNA
• Collaborate with internal and external teams to support characterization and evaluation of LNP formulations
• Assist with technology transfer and scale-up activities, including coordination with external partners or internal manufacturing teams
• Analyze and interpret experimental data, maintain accurate documentation, and communicate findings to project teams
• Stay current with advancements in LNP technologies and nucleic acid delivery approaches

Requirements

• PhD in Chemical Engineering, Pharmaceutical Sciences, Bioengineering, or related field with 3+ years of industry experience (or MS with 8+ years, or BS with 10+ years)
• Strong background in process development, scale-up, or manufacturing of nanoparticle or LNP-based systems
• Experience working with nucleic acid formulations such as mRNA or DNA is highly preferred
• Familiarity with T mixing, formulation scale-up, and characterization techniques like DLS and encapsulation assays
• Demonstrated ability to design experiments, analyze data, and solve complex technical problems
• Strong communication and collaboration skills

About the Company

Serif Biomedicines is a privately held, early-stage biotechnology company pioneering Modified DNA as a new class of medicines. Founded by Flagship Pioneering, Serif aims to enable medicines that are durable, redosable, programmable, and scalable.