Scientist – In Vitro High-Content Imaging Assay Development and Execution Supporting siRNA Programs

Responsibilities

• Design, develop, and validate quantitative cell-based transcriptional assays, including high-content RNA FISH and qRT-PCR, suitable for HTS and automation
• Implement assay miniaturization and automation workflows in collaboration with automation engineers to deliver reproducible, high-throughput runs
• Independently lead multiple screening projects, interpret results, and coordinate follow-up validation experiments
• Partner with Genetic Medicine and therapeutic-area teams to communicate technical recommendations and drive decisions for candidate progression
• Utilize high-content imaging assays and automation platforms to contribute to siRNA delivery, uptake, and cellular localization studies

Requirements

• Doctorate degree OR Master's degree with 2 years of In Vitro High-Content Imaging Assay Development experience OR Bachelor's degree with 4 years of experience
• Proven experience in In Vitro High-Content Imaging Assay Development

Preferred Qualifications

• Excellent cell culture techniques
• Experience with siRNA transfection and RNA FISH assays
• High-content imaging assay development using Opera Phenix
• Familiarity with lab automation instruments
• Strong critical thinking and troubleshooting skills

Benefits

• Comprehensive employee benefits package including medical, dental, vision, life, and disability insurance
• Retirement and Savings Plan with generous company contributions
• Discretionary annual bonus program
• Stock-based long-term incentives
• Award-winning time-off plans

About the Company

Amgen is a biotechnology pioneer dedicated to unlocking the potential of biology to serve patients living with serious illnesses. Since 1980, Amgen has focused on high unmet medical needs in areas such as Oncology, Inflammation, General Medicine, and Rare Disease, developing a deep pipeline of innovative medicines to improve human health outcomes worldwide.