Scientist II/Senior Scientist, Medicinal Chemistry

Responsibilities

• Design and advance medicinal chemistry strategies for next-generation induced proximity medicines, including PROTACs
• Lead compound design and SAR campaigns from hit finding through lead optimization
• Manage external chemistry CROs, including design prioritization, synthetic execution, and data review
• Direct external DMPK studies and interpret in vitro and in vivo data
• Partner with Biology and Platform teams to design screening strategies and support compound evaluation
• Contribute to mechanistic studies and intellectual property strategy through invention generation

Requirements

• PhD in Chemistry, Medicinal Chemistry, or a related field
• Minimum 3+ years of industry experience in small-molecule drug discovery
• Experience designing and optimizing induced proximity medicines (e.g., PROTACs)
• Proven success in hit-to-lead and lead optimization phases
• Experience optimizing compounds for oral exposure and interpreting pharmacokinetic data
• Deep understanding of physicochemical properties and in vitro DMPK parameters
• Experience managing external chemistry CROs

Preferred Qualifications

• Experience advancing programs from discovery into clinical development
• Background in computational chemistry, molecular modeling, or molecular dynamics
• Familiarity with chemical biology or structural biology techniques
• Experience with HTS or phenotypic screening
• Experience in proteomics or chemoproteomic target deconvolution

Benefits

• Strong equity incentives
• Top tier medical, dental, and vision coverage plus One Medical membership
• 401(k) retirement plans
• Education and health/fitness incentive programs
• Meditation retreats
• Reading budget

About the Company

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs) using their OmniTAC drug discovery engine to overcome therapeutic challenges.