Scientist II, Conjugation Development

Responsibilities

• Lead and execute experimental activities to support pneumococcal conjugate vaccine programs
• Optimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates
• Purify polysaccharides and conjugates using methods such as dialysis, size-exclusion chromatography, and tangential flow filtration (TFF)
• Analyze conjugates using various analytical methods and develop new laboratory workflows
• Advise team members on experimental design, result interpretation, and troubleshooting
• Serve as a subject matter expert during technical transfer to contract manufacturing organizations
• Maintain highly organized records and contribute to the authorship of laboratory protocols and development reports

Requirements

• PhD in chemistry, biochemistry, or related field with 2+ years of industry experience (or combination of industry and postdoctoral research)
• MS with 7+ years of industry experience, or BS with 10+ years of industry experience
• Strong biochemistry and organic chemistry knowledge base
• Proven experience preparing bioconjugates
• Proficiency in purification techniques, specifically tangential flow filtration (TFF)
• Proficiency in analytical techniques including HPLC and SEC-MALS
• Sufficient knowledge of analytical principles to develop fit-for-purpose methods
• Ability to work onsite in San Carlos, CA

Preferred Qualifications

• Experience with Design of Experiments (DoE)
• Experience with the chemical modification of polysaccharides
• Experience implementing or using electronic laboratory notebooks

About the Company

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. We are dedicated to tackling complex biologics to eradicate infections such as invasive pneumococcal disease, Group A Strep, and Shigella.