Scientist I

About the Company

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. Our work is guided by core values of rethinking convention, aiming high, leading with heart, and modeling excellence.

Responsibilities

• Independently design and execute experiments to support analytical characterization of proteins, drug substances, and conjugates
• Develop and optimize HPLC-based separation methods including AEX, SEC, and SEC-MALS
• Design and implement mass spectrometry-based workflows for detailed molecular characterization
• Analyze and interpret complex datasets and drive solutions forward
• Maintain accurate and detailed records using an electronic laboratory notebook (ELN)
• Collaborate with cross-functional partners to support project goals and deliver high-quality analytical data
• Communicate findings clearly through presentations and discussions

Requirements

• PhD with 1-2 years, MS with 5+ years, or BS with 8+ years of relevant industry experience in analytical development or QC
• Proven experience in HPLC method development and optimization (AEX, SEC, SEC-MALS)
• Strong understanding of chromatographic principles
• Hands-on experience with LC-MS, including peptide mapping and intact mass analysis
• Familiarity with mass spectrometry platforms such as Orbitrap, Q-TOF, or triple quadrupole
• Strong analytical thinking and troubleshooting skills
• Excellent documentation and organizational skills