Scientist I, Protein Purification & Expression

About the Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases.

Responsibilities

• Maintain insect cell and mammalian cell cultures
• Execute all operational activities for analytical and preparative scale expression of recombinant proteins in baculovirus and mammalian cell systems
• Manage baculovirus expression steps including clone design, bacmid generation/purification, and virus titering
• Conduct MOI studies and harvest biomass on scales of 1 L – 20 L
• Perform protein characterization including SDS-PAGE, size exclusion chromatography, and thermal stability analysis
• Document expression conditions and results in internal databases and electronic lab notebooks

Requirements

• Ph.D. or equivalent with 2+ years of relevant experience
• 2+ years of experience with insect cell lines and baculovirus expression
• Ability to work in a dynamic, fast-paced environment
• Strong record keeping and detail-oriented skills
• Ability to lift 50+ pounds comfortably

Preferred Qualifications

• Experience with recombinant protein expression in mammalian cells (e.g. HEK293)
• Industry experience overexpressing milligram amounts of protein for structural and functional studies
• Experience purifying recombinant proteins via affinity, ion exchange, or size exclusion chromatography