Scientist I, In Vitro Pharmacology

Responsibilities

• Design and execute cell-based and biochemical assays to assess Syntein™ activity, target engagement, and mechanism of action
• Conceptualize and develop novel assays for diverse target classes and disease areas
• Collaborate with the Pharmacology team on biochemistry and biophysics projects, providing cell biology expertise
• Contribute to in vivo and ex vivo pharmacology activities to progress projects and the platform
• Work cross-functionally to enable novel methods, assays, and screening workflows, including assay optimization for screening funnels
• Ensure rapid generation and accurate reporting of high-quality data to drive design-make-test cycles
• Communicate scientific findings and ideas effectively to diverse internal teams

Requirements

• PhD in molecular biology, cell biology, or a related discipline (up to 2 years of relevant experience; industry experience preferred)
• Technical expertise in mammalian cell culture, including cell line maintenance, transient/stable transfection, and lentiviral transduction
• Proficiency in bioanalytical techniques such as TR-FRET, ELISA, Western blot, and flow cytometry
• Experience with primary cell culture and characterization, including tissue dissociation
• Demonstrated ability to independently design, develop, and optimize diverse cell-based functional assays
• Strong ability to work in a fast-paced, team-oriented environment

Preferred Qualifications

• Experience with cellular/high-content imaging and image analysis (e.g., Incucyte, Phenix)
• Proficiency in renal disease biology and preclinical kidney models
• Experience with in vivo pharmacology
• Proficiency in laboratory automation and semi-automated screening workflows
• Industry-level experience with data record maintenance and workflow integrity

Benefits

• Healthcare coverage
• Annual incentive program
• Retirement benefits
• A broad range of other company benefits