Scientist I, Immune Evasion

Responsibilities

• Independently execute and support high-throughput immune evasion (IE) assays, including antibody neutralization and total antibody immunoprecipitation (tAb IP) workflows
• Own the day-to-day operation, optimization, and troubleshooting of immune evasion assay platforms
• Analyze, interpret, and communicate immune evasion screening data to cross-functional stakeholders
• Contribute to the expansion of immune evasion capabilities including re-dosing, T-cell responses, complement activation, and innate immunity
• Partner with Immune Evasion, CNS, Muscle, and in vivo teams to identify technical gaps and improve assay throughput
• Support long-term development of internal discovery capabilities, including high-throughput library cloning and production workflows

Requirements

• Ph.D. in Immunology, Cell/Molecular Biology, or a closely related discipline
• Deep understanding of immune mechanisms relevant to gene therapy
• Hands-on experience with immunological assays (e.g., immunoprecipitation, ELISA, neutralization, ELISPOT)
• Experience with molecular biology techniques (qPCR, flow cytometry, NGS library prep, NGS-based experimental design)
• Prior experience with antibody biology and/or adaptive immune responses
• Strong experimental design and troubleshooting skills
• Foundational knowledge of statistical methods for data analysis
• Effective scientific communication skills

Preferred Qualifications

• Familiarity with in vivo models of immune response
• Experience designing and working with high-throughput libraries or large-scale screening workflows
• Working knowledge of Python or R for data analysis
• Exposure to AAV biology, gene therapy, or viral vector engineering

About the Company

Dyno Therapeutics is a high-energy team on a mission to build high-performance genetic technologies that transform patient lives, working at the intersection of AI and genetic medicine.