Scientist, Bioconjugation

Responsibilities

• Design, execute, and troubleshoot bioconjugation reactions for protein-oligonucleotide conjugates and other bioconjugated fluorophores, tags, and peptides
• Purify and characterize bioconjugated products using standard biochemical techniques
• Build and maintain a parallelized, efficient workflow to support in vivo target engagement evaluation
• Oversee contract research organizations (CROs) performing specialized or large-scale bioconjugation projects
• Proactively identify and drive optimization of existing bioconjugation and analytical workflows
• Maintain accurate, detailed experimental records and contribute to scientific discussions

Requirements

• PhD in Biochemistry, Chemistry, Molecular Biology, or a related scientific field
• Minimum of 3+ years of hands-on wet-lab experience in protein production, purification, and biochemistry
• Proficiency in basic biochemical techniques (e.g., protein quantification, gel electrophoresis, chromatography)
• Proven ability to troubleshoot biochemical assays and optimize experimental protocols
• Experience with bioconjugation chemistry principles and methodologies
• Familiarity with oligonucleotide chemistry and handling

Preferred Qualifications

• Experience with high-throughput screening or automation
• Familiarity with analytical techniques for biomolecule characterization (e.g., mass spectrometry, DLS, BLI, SPR)
• Experience establishing and troubleshooting enzymatic assays
• Demonstrated leadership or mentorship of junior scientists
• Strong presentation skills and design sensibility

Benefits

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• On-site gym, onsite lunch, and commuter support

About the Company

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems.