Scientist, Analytical Development and Quality Control

Responsibilities

• Conduct analytical method development and material characterization studies to inform drug substance and drug product development
• Perform 2D-LC for impurity profiling and structural elucidation using high resolution Orbitrap Tribrid Mass Spectrometry
• Utilize QbD HPLC method development with multivariate DOE software
• Execute forced degradation studies and elucidate degradation mechanisms
• Manage reference standards, impurity markers, and technical documentation
• Provide operational oversight and troubleshooting for external CDMO/CTL partners
• Collaborate with Medicinal Chemistry, Bioanalytical, DMPK, and Preclinical departments
• Ensure compliance with cGMP quality standards and internal SOPs

Requirements

• Advanced degree in Chemistry, Pharmaceutics, or a related field (BS with 10+ years, MS with 6+ years, or PhD with up to 4 years of experience)
• Expertise in the operation and maintenance of mass spectrometers
• Hands-on experience with HPLC operation and method development
• Ability to critically interpret data and communicate technical concepts to cross-functional teams
• Strong interpersonal and collaborative skills

Preferred Qualifications

• Experience with Orbitrap Tribrid mass spectrometers
• Hands-on experience with 2D-LC
• Experience determining structures of small molecule impurities or metabolites
• Experience with protein or ADC characterization via mass spectrometry
• Familiarity with GC, NMR, particle size analysis, solid state characterization, dissolution, ICP-MS/OES, or FTIR
• Experience with reference standard management, stability programs, or method validation
• Familiarity with ICH guidelines, cGMPs, and pharmacopeial chapters

About the Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines to improve treatment options for patients with cancer and inflammatory diseases.