Scientific Associate Director - Safety Pharmacology

Responsibilities

• Lead safety pharmacology lab-based activities and manage the cardiac safety and electrophysiology laboratory staff
• Oversee in vitro and in vivo safety pharmacology studies, including protocol development, data review, and report finalization
• Serve as a Safety Pharmacology Subject Matter Expert (SME) on project teams to support discovery and development programs
• Ensure appropriate evaluation of target- and off-target-based safety risks in accordance with ICH guidelines
• Manage exploratory and GLP-compliant studies, including the oversight of outsourced studies and CRO relationships
• Build and maintain external scientific collaborations with academic and industry partners to advance safety pharmacology best practices
• Contribute to scientific eminence through peer-reviewed publications and presentations

Requirements

• Doctorate with 4 years of relevant scientific experience, OR Master's degree with 7 years of experience, OR Bachelor's degree with 9 years of experience
• Experience in in vitro and/or in vivo safety pharmacology
• Laboratory management and people leadership experience
• Strong cross-functional communication and problem-solving skills

Preferred Qualifications

• PhD in Pharmacology, Neuroscience, Physiology, Biomedical Sciences, or a related field
• Working knowledge of cardiac ion channel assays (e.g., hERG, Nav1.5, Cav1.2) and hiPSC-derived cardiomyocyte assays
• Experience supporting discovery and development project teams as a safety pharmacology SME
• Familiarity with GLP-enabling safety pharmacology packages and integration with toxicology studies
• Track record of scientific publications and participation in external scientific forums

Benefits

• Comprehensive employee benefits package including medical, dental, and vision coverage
• Retirement and Savings Plan with generous company contributions
• Discretionary annual bonus program
• Stock-based long-term incentives
• Award-winning time-off plans

About the Company

Amgen is a leading biotechnology company dedicated to unlocking the potential of biology to serve patients living with serious illnesses. Since 1980, Amgen has pioneered innovations in oncology, inflammation, general medicine, and rare diseases, leveraging advanced human genetics and biologics manufacturing expertise to improve health outcomes worldwide.