Research Associate or Associate Scientist, Genome Engineer

About the Company

Conception is pioneering the future of reproductive biology by generating functional human eggs from induced pluripotent stem cells. Our mission is to unlock new possibilities for fertility, reproductive health, and genetic diversity.

Responsibilities

• Build engineered cell lines including reporter, knock-out, knock-in, and overexpression lines
• Use CRISPR-based genome engineering to design, generate, screen, and validate edited cell lines
• Develop DNA-integrating expression systems for constitutive and inducible transgene expression
• Optimize workflows for transfection, transduction, selection, clonal isolation, and expansion
• Build assays to track reporter activity, transgene expression, and differentiation states
• Support differentiation experiments and collaborate across cross-functional teams

Requirements

• Bachelor's or Master's degree in Cell Biology, Molecular Biology, Stem Cell Biology, Bioengineering, Genetics, Synthetic Biology, or related field
• Hands-on experience with mammalian cell culture and cell engineering workflows
• Experience with CRISPR genome engineering (knock-out, knock-in, or reporter line generation)
• Experience with DNA delivery or integrating expression systems (plasmid transfection, viral transduction, PiggyBac, Sleeping Beauty, or lentiviral systems)
• Experience with validation assays such as PCR, genotyping, sequencing, flow cytometry, imaging, qPCR, or immunostaining
• Strong experimental execution, troubleshooting, and data interpretation skills

Preferred Qualifications

• Experience with iPSCs, ESCs, primary cells, or differentiating cells
• Experience building reporter lines to track gene expression or cell state
• Experience with inducible or constitutive expression systems and promoter testing
• Experience with CRISPRa, CRISPRi, or dCas9-based systems
• Familiarity with stem cell differentiation, developmental biology, or organoid systems