Research Associate III/Scientist I, DNA Encoded Library Technology

Responsibilities

• Design and validate novel DNA-encoded library (DEL) builds
• Develop new DNA-compatible chemical transformations to expand DEL chemical space
• Construct DEL libraries to support in-house production efforts
• Work with external partners on DEL synthesis and hit follow-up strategies
• Engage in cross-functional discussions regarding DEL screening, data analysis, machine learning, and hit-optimization
• Contribute to platform automation and technology development
• Present results and document workflows within the Discovery Chemistry organization

Requirements

• B.S. or higher in Chemistry, Biochemistry, or Medicinal Chemistry
• 2–5 years of industrial experience
• Strong background in synthetic organic chemistry
• Hands-on laboratory experience synthesizing DNA encoded libraries
• Familiarity with DNA-Encoded Library Technology workflow operations
• Experience analyzing and purifying DNA-conjugates using LCMS/HPLC

Preferred Qualifications

• Experience in drug discovery, drug design, synthesis, and SAR-based hit-to-lead optimization
• Experience with high-throughput analytical and purification systems for DEL applications
• Experience with molecular biology tools such as PCR, qPCR, and Western Blot

About the Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines for cancer and inflammatory diseases.