Research Associate II, Preclinical Manufacturing

About the Company

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology and an industry-leading platform of programmable nanoparticles to unlock comprehensive programming of medicines.

Responsibilities

• Support the production of RNA cargo molecules and lipid nanoparticle (LNP) formulations for preclinical studies
• Execute hands-on laboratory work involving eRNA synthesis, purification, and LNP encapsulation
• Contribute to the development, optimization, and scale-up of high-yield, high-quality RNA/LNP processes
• Operate and maintain lab-scale instrumentation, including AKTA (FPLC), TFF systems, PCR, HPLC, capillary electrophoresis, UV-Vis, and light scattering platforms
• Perform analytical characterization and quantification of RNA and other nucleic acids
• Analyze experimental data and document results in electronic lab notebooks (ELN) and technical reports
• Collaborate cross-functionally with research, analytical, and process development teams

Requirements

• B.S. with 2+ years of industry experience or M.S. in Molecular Biology, Biochemistry, Biochemical Engineering, or a related field
• Hands-on experience in RNA/DNA production and purification, LNP formulation, chromatography (AKTA/FPLC, HPLC), TFF, or automated liquid handling
• Strong understanding of experimental design, data analysis, and technical documentation
• Proficiency in aseptic technique, buffer preparation, and instrument operation

Preferred Qualifications

• Experience with analytical methods such as capillary electrophoresis, UV-Vis, or light scattering
• Detail-oriented with strong organizational and documentation skills
• Effective communicator with the ability to clearly present technical data and insights