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Posted 15 hours ago
Principal/Senior Scientist, PK/PD Assays
NewLimitPrincipal/Senior Scientist, PK/PD Assays
Perks & benefits
CommissionHealth InsuranceMedical InsurancePaid Leave
Requirements
PhD in molecular biology, biochemistry, or cell biology, 3+ years experience in quantitative bioanalytical assay platforms, Knowledge of bioanalytical method qualification/validation principles, Experience with primary cell culture and tissue-derived sample workflows
Skills
Molecular BiologyPharmacokineticsAssay Development
About the role
About the Company
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells.
Responsibilities
- Own the end-to-end design, development, and qualification of PK and PD biomarker assays across various platforms to support preclinical and IND-enabling studies
- Discover and validate pharmacodynamic biomarkers to support the clinical development of drugs across multiple programs
- Drive data analysis, interpretation, and reporting for bioanalytical studies to support program decision-making with audit-ready data packages
- Contribute to sample processing workflows including tissue harvesting, primary cell culture, and complex matrix handling
- Mentor research associates, establish SOPs, and build institutional knowledge within the bioanalytical function
Requirements
- PhD in molecular biology, biochemistry, cell biology, or a related field or equivalent industry experience (5+ years)
- 3+ years of hands-on experience in various quantitative bioanalytical assay platforms (e.g., RT-qPCR, ddPCR, ELISA, MSD, Olink, SOMAscan, NGS-based methods) in complex biological matrices
- Strong working knowledge of bioanalytical method qualification/validation principles for PK/PD biomarker measurements
- History of delivering results for bioanalytical projects
- Experience with primary cell culture and tissue-derived sample workflows
Preferred Qualifications
- Track record of bioanalytical method transfer and CRO management for outsourced projects
- Familiarity with preclinical drug development timelines and regulatory submissions
- Experience with mRNA-LNP biodistribution or nucleic acid–based PK assays
- Experience developing products in emerging therapeutic modalities
Benefits
- Comprehensive Health, Dental, and Vision insurance
- 401(k) plan with company match
- Paid parental leave
- Industry-leading PTO: 20 days per year plus holidays
- On-site meals and snacks
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NewLimit · South San Francisco
