Principal Scientist – Protein Formulation & Biophysical Characterization

Responsibilities

• Design and execute experimental studies to develop and optimize protein formulations for various modalities, including mAbs, fusion proteins, and ADCs.
• Apply biophysical and physicochemical characterization to assess and mitigate risks such as aggregation, viscosity, and stability.
• Develop novel formulation strategies and scalable technologies for high-concentration biologics and subcutaneous delivery.
• Lead cross-functional technical initiatives and serve as a subject matter expert for project teams and regulatory documentation.
• Build external scientific presence through academic collaborations, publications, and conference presentations.

Requirements

• PhD in Pharmaceutics, Biochemistry, Biophysical Sciences, or a related field.
• 3–5 years of experience in biologics formulation, biophysics, or drug product development.
• Strong background in protein formulation for parenteral biologics.
• Hands-on proficiency with biophysical characterization techniques including DLS, DSC, DSF, SEC-MALS, NTA, CD, and FTIR.
• Ability to analyze complex data and communicate actionable scientific insights.

Preferred Qualifications

• Demonstrated scientific output through publications or conference presentations.
• Expertise in protein design, structure-function relationships, and identifying developability hot spots.
• Deep understanding of high-concentration challenges such as viscosity, self-association, and colloidal instability.
• Experience with non-mAb modalities like oligonucleotides or peptides.
• Knowledge of molecular modeling, machine learning, or AI approaches for protein behavior prediction.

Benefits

• Competitive annual base salary with performance-based bonus eligibility.
• 401(k) plan with Pfizer matching contributions and additional retirement savings contributions.
• Comprehensive health benefits including medical, prescription drug, dental, and vision coverage.
• Paid vacation, holidays, personal days, and parental/medical leave.

About the Company

Pfizer is a global leader in the pharmaceutical industry, dedicated to discovering and developing innovative therapies to improve healthcare and transform lives worldwide.