Principal Bioinformatics Scientist

Responsibilities

• Act as a thought leader in the planning, design, and execution of complex bioinformatics projects to support molecular diagnostics and product development.
• Develop, plan, and analyze results from experiments to inform project progression and identify technical discrepancies.
• Independently plan and develop algorithms and determine methods or technologies for future product concepts.
• Provide deep scientific input for experimental design and participate in decisions affecting product development.
• Prepare and present complex data-driven outcomes and technical findings to senior management and at scientific conferences.
• Contribute to the intellectual property portfolio by implementing innovative solutions and assisting with IP filings.
• Train, guide, and mentor junior bioinformatics scientists.
• Generate and communicate detailed technical documentation, including development plans, protocols, and reports.

Requirements

• PhD in bioinformatics, computational biology, computer science, mathematics, or a related field.
• 9+ years of industry or academia experience in bioinformatics.
• 8+ years of experience in molecular diagnostics, biotech, or life science (including IVD/LDT development).
• Demonstrated expertise in genomics and next-generation sequencing (NGS).
• Proven experience in developing statistical and quantitative methods.
• Demonstrated leadership in product or assay research, design, or development.

Preferred Qualifications

• 15+ years of experience in medical device, IVD, biotech, or pharmaceutical industries.
• Experience applying advanced statistical learning methods (supervised/unsupervised) and AI techniques like deep learning or neural networks to high-dimensional data.
• Previous experience developing algorithms in Molecular Diagnostics or liquid biopsy NGS.
• Familiarity with the software development lifecycle, DevOps concepts, and design control processes for IVD assay development.
• Experience with project management tools such as SmartSheet or MS Projects.

Benefits

• Paid time off including vacation, holidays, volunteering, and personal time.
• Paid leave for parents and caregivers.
• Retirement savings plan.
• Comprehensive wellness support and health benefits (medical, prescription drug, dental, and vision).

About the Company

Exact Sciences is helping change how the world prevents, detects, and guides treatment for cancer. We provide patients and clinicians with the clarity needed to make confident decisions when they matter most.