Postdoctoral Researcher

Responsibilities

• Design and execute independent research projects centered on 3D genome organization in cancer
• Perform and optimize chromatin conformation assays, including HiChIP, HiC and related targeted 3D genome methods
• Generate and integrate complementary epigenomic datasets, including ATAC-seq, CUT&RUN, CUT&Tag
• Contribute to or initiate single-cell and spatial multi-omics projects
• Work with patient-derived organoid models
• Perform and optimize NGS library preparation protocols across multiple assay types
• Collaborate closely with computational scientists for data analysis and interpretation
• Lead manuscript preparation and contribute to grant development
• Mentor trainees and contribute to a collaborative lab environment

Requirements

• Ph.D. in Molecular Biology, Cancer Biology, Genomics, or a related field
• Strong experimental background in functional genomics and epigenomics assays
• Hands-on experience with next-generation sequencing (NGS) library preparation
• Experience with chromatin-based assays (e.g., ATAC-seq, HiC-based methods, CUT&RUN)
• Proven ability to independently design and execute experiments
• Strong publication record
• Excellent communication skills and fluency in English
• Ability to work effectively in a collaborative, multidisciplinary environment

Preferred Qualifications

• Direct experience with 3D genome assays (Hi-C, HiChIP, Capture-C)
• Experience with organoid culture systems
• Exposure to single-cell or spatial genomics technologies
• Basic familiarity with computational analysis using R or Python

Benefits

• Competitive offer packages
• Healthcare of Ontario Pension Plan (HOOPP)
• Access to transit and UHN shuttle service
• Flexible work environment
• Opportunities for development and promotions
• Corporate discounts (travel, restaurants, parking, etc.)

About the Company

UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. As Canada's top research hospital, UHN is a national and international source for discovery, education and patient care, with major research in neurosciences, cardiology, oncology, and genomic medicine.