Pharmacology Principal Research Associate

Responsibilities

• Design, execute, and interpret in vivo experiments to evaluate compound effects on disease biology
• Lead flow cytometry analysis and cell sorting workflows for ex vivo samples from rodent and large animal studies
• Perform sample preparation, staining, acquisition, panel optimization, and gating analysis
• Conduct in vivo procedures including animal handling, dosing via multiple routes, perfusion, and tissue dissection
• Perform analytical assays such as ELISA on serum and urine samples
• Prepare clear protocols, study plans, and reports, and present findings to internal teams
• Independently troubleshoot experimental challenges and refine protocols

Requirements

• Bachelor’s degree in a biological science
• 5+ years of experience with a Bachelor’s degree, or 2+ years of experience with a Master’s degree
• Strong technical expertise in flow cytometry and cell sorting
• Hands-on experience with in vivo pharmacology techniques (animal handling, dosing, perfusion, etc.)
• Experience performing ELISA assays

Preferred Qualifications

• Background in muscular dystrophy and/or cystic kidney disease
• Experience with complex dataset interpretation and statistical analysis

Benefits

• Medical, dental, and vision benefits
• Generous paid time off, including a week-long company shutdown in Summer and Winter
• Educational assistance programs and student loan repayment
• 401(k) with company matching
• Annual bonus and annual equity awards

About the Company

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases and continues to advance a robust clinical pipeline across various modalities.