Engineer II, Upstream Development

Responsibilities

• Lead operational activities related to bioreactor set-up, monitoring, harvest, and maintenance
• Develop, test, and implement recipe scripting for fed-batch fermentation feeding controls
• Provide engineering support for the design, implementation, and qualification of scale-down models
• Author SOPs, process flow diagrams, and batch records
• Analyze and present fermentation data at internal project meetings
• Participate in upstream database management and documentation in electronic notebooks

Requirements

• BS in Chemical Engineering or a related discipline with 10+ years of experience, MS with 7+ years, or PhD with 2-5 years of relevant Pharma/Biotech industry experience
• Hands-on experience with fermentation and/or primary recovery unit operations
• Strong understanding of the fundamentals of bioreactor design, operation, and controls
• Proven knowledge of aseptic techniques
• Familiarity with Design of Experiments (DoE) principles and software

Preferred Qualifications

• Experience operating and maintaining bioreactors at laboratory scale, including Ambr® 250
• Experience with pilot scale fermentation and recovery equipment
• Mechanical and technical knowledge of primary recovery unit operations such as homogenization, centrifugation, and depth filtration
• Understanding of fermentation scale-up and development of scale-down models
• Familiarity with regulatory requirements of biotherapeutics and late-stage process characterization experience

About the Company

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. We are driven by core values of rethinking convention, aiming high, leading with heart, and modeling excellence.