Director/Senior Director, Medicinal Chemistry

Responsibilities

• Lead a group of project scientists and drive molecular discovery efforts to deliver development and clinical candidates
• Devise strategies to execute hit ID, identify lead molecules and optimize them for potency, selectivity, and ADME properties
• Act as a liaison between Iambic, CROs, and other external collaborators
• Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation
• Work closely with AI/ML teams to develop and implement predictive models for molecule design
• Contribute to platform development by collaborating with AI/ML and chemistry automation teams
• Communicate project updates clearly to the broader team and key stakeholders
• Foster a culture of scientific excellence, innovation, and teamwork

Requirements

• Ph.D. in Organic Chemistry with 15+ years of Pharma/biotech drug discovery experience or MS/BS with 20+ years of experience
• Expertise in modern synthetic organic chemistry
• Proven cross-functional leadership integrating biology, DMPK/ADME, CADD, and CMC
• Practical experience with target protein degradation and associated modalities (molecular glues, PROTACS)
• Track record of advancing compounds through preclinical development
• Experience working with computational chemists in drug target design
• Experience mentoring or leading junior chemists

Benefits

• Industry leading competitive pay
• Company paid healthcare
• Flexible spending accounts
• Voluntary life insurance
• 401K matching
• Uncapped vacation
• Onsite gym and dining

About the Company

Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego, Iambic unites pioneering AI experts and experienced drug hunters to deliver new drug candidates to human clinical trials with unprecedented speed.