Director - Targeted Protein Degradation

Responsibilities

• Provide scientific leadership for Amgen's targeted protein degradation strategy within the Induced Proximity Platform (IPP).
• Define and execute a long-term scientific vision to expand the reach of the degrader platform into new biological spaces and modalities.
• Drive innovation across the TPD landscape, including molecular glues, heterobifunctional degraders, and tissue-selective degraders.
• Build and mentor a high-performing multidisciplinary team of scientists across chemical biology, proteomics, and drug discovery.
• Champion the integration of AI and data-driven approaches into target identification and ligand discovery.
• Establish strategic external partnerships and identify capability gaps to maintain scientific leadership.
• Partner with Therapeutic Areas, Medicinal Chemistry, and Translational Sciences to maximize platform impact.

Requirements

• Doctorate degree and 4 years of scientific experience, OR Master's degree and 8 years of scientific experience, OR Bachelor's degree and 10 years of scientific experience.
• At least 4 years of experience directly managing people and/or leading teams, projects, or programs.

Preferred Qualifications

• PhD in Chemical Biology, Biochemistry, Molecular Biology, Pharmacology, Medicinal Chemistry, or a related scientific discipline.
• Recognized scientific leader with significant contributions to targeted protein degradation or molecular glues.
• Deep expertise in E3 ligase biology, chemical proteomics, structural biology, and translational pharmacology.
• Experience building research capabilities and driving organizational transformation.
• Strong understanding of emerging computational and AI-enabled approaches in drug discovery.

Benefits

• Comprehensive employee benefits package including medical, dental, vision, life, and disability insurance.
• Retirement and Savings Plan with generous company contributions.
• Discretionary annual bonus program and stock-based long-term incentives.
• Award-winning time-off plans and flexible work models where possible.

About the Company

Amgen is a leading biotechnology company dedicated to unlocking the potential of biology to serve patients living with serious illnesses. Since 1980, Amgen has pioneered innovative medicines across Oncology, Inflammation, General Medicine, and Rare Disease.